IndraLab

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Glutathione inhibits NFKBIA. 2 / 2
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"PL increased ROS (measured by DCFH-DA), reduced glutathione, activated p38 and JNK, increased IkappaBalpha, and suppressed NFkappaB in LN229 cells after scratching."
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"We show that in contrast to wt mice, GSH depleted mouse livers have persistent hepatic IkappaBalpha at 30 minutes after TNF-alpha injection, indicating that proteasomal degradation of IkappaBalpha is delayed and is possibly responsible for the inhibition of NFkappaB activation in these animals."
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