IndraLab

Statements

USP25 activates GATA3. 7 / 7
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"USP21 positively regulates and stabilizes GATA3, which can maintain FOXP3 expression."
26441996
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"In a search for DUBs that contribute to GATA3 stabilization in FOXP3-expressing cells, both USP7 and USP21 were shown to upregulate GATA3-mediated activity using a reporter assay ."
28959952
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"Interestingly, Foxp3 directly activates expression of USP21, and siRNA knockdown of USP21 downregulates both GATA3 and Foxp3 protein."
26085205
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"Overexpression of USP21 can rescue GATA3 from its degradation so as to stabilize the expression of GATA3 [XREF_BIBR]; RT-PCR showed that the mRNA of USP21 is upregulated in the Treg cells of asthma patients."
30013989
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"In a search for DUBs that contribute to GATA3 stabilization in FOXP3-expressing cells, both USP7 and USP21 were shown to upregulate GATA3-mediated activity using a reporter assay 131 ."
28959952
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"Expression of USP21 leads to stabilize GATA3."
28279784
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"In summary, we have identified a USP21 mediated pathway that promotes GATA3 stabilization and expression at the post-translational level."
23395819