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COPS6 activates UBR5. 2 / 2

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"Furthermore, in CSN6-knockdown melanoma cells, UBR5 knockdown abrogated the effects caused by CSN6 silencing, suggesting that CSN6 activates the UBR5 and CDK9 pathway to promote melanoma cell proliferation and metastasis."

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"Then, western blot analysis showed that the proteasome inhibitor MG132 could rescue CSN6 mediated UBR5 downregulation."

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IndraLab

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COPS6 activates UBR5. 2 / 2

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