IndraLab

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UCHL1 inhibits Alzheimer Disease. 5 / 9
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"Recent studies reported that the level of soluble UCHL1 protein is inversely proportional to the number of tangles, that UCHL1 is oxidized in AD brains and that overexpression of UCHL1 reverses cognit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCHL1 can promote the degradation of APP and BACE1 in AD ."
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"Inhibition of UCHL1 activity significantly increased BACE1 protein expression and increased concentrations of amyloid β, whereas overexpression of UCHL1 decreased amyloid β levels and delayed AD progression (Zhang et al., 2014; Zhang et al., 2012)."
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"Zhang et al. reported that the overexpression of UCHL1 decreased Abeta in the uchl1-null AD mice (Zhang et al., 2012)."
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"Inhibition of UCHL1 activity significantly increased concentrations of amyloid β, whereas overexpression of UCHL1 decreased amyloid β levels and delayed AD progression [51]."
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