IndraLab

Statements

USP18 leads to the phosphorylation of STAT1. 4 / 4
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"The scheme of HCV- and ethanol-induced regulation of IFNα-induced STAT1 phosphorylation by USP18 is presented as xref ."
27716962
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"We conclude that acetaldehyde disrupts IFNα-induced STAT1 phosphorylation by the upregulation USP18 to block the innate immunity protection in HCV-infected liver cells, thereby contributing to HCV-alcohol pathogenesis."
27716962
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"The second mechanism is the recently described inhibition of STAT1 phosphorylation by UBP43 (the product of ISG43 ) through its inhibition of JAK1 interaction with the IFNAR2 subunit of the type I IFN receptor xref ."
19551150
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"We have previously shown that Usp18 Ity9 mice on a mixed background have increased levels of Ifnb transcript and increased STAT1 phosphorylation downstream of the receptor."
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