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TNF decreases the amount of THBD. 68 / 72
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"PTX counterbalanced the TNF induced suppression of TM expression."
1656544
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"Thromobomodulin transgene expression driven by the enhanced PAI-1 promoter in rAAV vector transduced cultured endothelial cells was between 600- and 1000-fold higher than constitutive thrombomodulin gene expression in cultured human umbilical vein endothelial cells and was up-regulated by TGFbeta1 and TNFalpha stimulation which may down-regulate endogenous thrombomodulin gene expression in endothelial cells."
11892836
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"Tumor necrosis factor (TNF)-alpha (50 ng/ml) or lipopolysaccharide (20 microg/ml) downregulated the expression of endothelial thrombomodulin."
18685431
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"Tumor necrosis factor or interleukin-1 beta suppressed surface TM activity and TM mRNA levels."
1645358
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"7 , 8 , 9 IL‐17A and TNF also promote expression of tissue factor (TF) leading to activation of the coagulation cascade while inhibiting expression of the anticoagulant protein thrombomodulin, favoring blood clotting and thrombosis."
39800890
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"Consistent with previous reports 26, we found that TNF-alpha treatment significantly decreased TM expression in HUVECs, which was substantially reversed in ECs overexpressing either Nur77 or Nor1 (XREF_FIG)."
26634653
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"ATA increased endothelial thrombomodulin expression that was downregulated by TNF-alpha or lipopolysaccharide, in a dose dependent manner."
18685431
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"33 TNF reduced the expression of thrombomodulin in ECs by 4.5‐fold (Figure 4B)."
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"TNF has also been shown to increase tissue factor procoagulant activity, enhance IL-1 and plasminogen activator inhibitor-1 and suppress expression of thrombomodulin as well as cofactor activity ofpro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8390056
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"Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression."
1309855
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"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells."
22682140
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"Of note, the expression of membrane thrombomodulin (TMD) is decreased by TNF-alpha."
18668398
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"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells."
21239288
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"However, TNF‐α stimulation attenuated surface expression of TM and EPCR already at 1 ng/ml TNF‐α (Figure 1E), which is consistent with the literature, 26 thus potentially suppressing this pathway, which has been confirmed in patients with AF."
35037739
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"In HAECs, TNFalpha treatment decreased the expression of TM in a time- and dose dependent manner and atorvastatin pretreatment upregulated the expression of TM mRNA and protein in HAECs with or without TNFalpha treatment."
19609862
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"TNF suppresses transcription of the thrombomodulin gene in endothelial cells and may affect coagulation [XREF_BIBR]."
23459312
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"IL-1 and tumor necrosis factor (TNF) induce changes in the hemostatic properties of endothelial cells surface which leads to increased tissue factor and decrease thrombomodulin expression and suppression of protein C activity."
10352499
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"We have previously reported that TNF-alpha decreases the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells [36]."
17949793
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"[XREF_BIBR, XREF_BIBR] For example, TNF-alpha inhibits the transcription of TM and EPCR in endothelial cells through the NF-kappaB pathway, as well as promotes the secretion of matrix metalloproteinases, mainly MMP-2, which hydrolyses cellsurface membrane receptors resulting in shedding of TM and EPCR."
28538400
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"For the first time, we showed that TNF-alpha induced the increased levels of TF antigen and activity, and reduced the antigen levels of TM in ECs (XREF_FIG)."
25162582
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"Endotoxin, IL-1beta and TNF-alpha inhibit the expression of thrombomodulin and the endothelial cell protein C receptor, thus reducing the formation of activated protein C and inhibiting its anticoagulant activity [XREF_BIBR, XREF_BIBR]."
28208708
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"Moreover, some evidence has also indicated that the endotoxin LPS, and the cytokines TNF-alpha and interleukin-1beta, have regulatory effects on TM expression in phagocytes XREF_BIBR but inhibit TM expression in endothelial cells."
23383040
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"TNF-alpha downregulates the expression of thrombomodulin and protein C receptor in ECs."
32208336
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"Some reports have also indicated that the inflammatory cytokine TNF-alpha inhibits TM expression by affecting the activation of NF-kB XREF_BIBR, XREF_BIBR."
23383040
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"The results showed that TNF-alpha decreases the TM expression by mediating posttranscriptional modification, and this inhibition may be repressed by treatment with propofol."
21610570
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"In addition, the expression of TM can be reduced by TNFα, IL-1β, and endotoxin, which cause proteolytic cleavage, internalization, and suppression of transcription (56)."
34490308
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"Western blotting of lysates of THP-1 cells versus cultured human umbilical vein endothelial cells showed that after 24 h of stimulation, TNF-alpha decreased TM protein expression in endothelial but not THP-1 cells and comparable responses were noted by flow cytometry."
9594445
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"TNF decreased HUVEC expression of THBD, and PROCR, and increased F3 levels while increasing TF and FIX production."
32029851
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"Conversely, the expression levels of THBD and PROCR (gene for EPCR) are reduced by TNF ."
32029851
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"In addition, TNF-alpha and IL-1 may suppress endothelial fibrinolytic activity and downregulate thrombomodulin expression, diminishing the activation of protein C [66]."
15056060
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"For example, TNF-α and IL-1β can induce the expression of TF by vascular endothelial cells and downregulate the expression of thrombomodulin, the surface receptor for thrombin leading to reduced activation of the protein C system, which is one of the main anticoagulant defence systems [14]."
34603868
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"Another study demonstrated that tumor necrosis factor (TNF) stimulates mRNA and protein expressions of tissue factor as well as inhibits the expressions of mRNA and protein of thrombomodulin in cultured endothelial and monocytic cells."
36904113
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"Tumor necrosis factor alpha (TNFalpha) suppresses TM expression."
25039491
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"Tumor necrosis factor alpha (TNFalpha) suppresses TM expression."
25039491
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"Both TNFa and IL-113 induce and upregulate theexpression of tissue factor in endothelial cells [62,63], and downregulate the expression of thrombomodulin and fibrinolytic activity [49,64]."
27419881
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"Tumor necrosis factor alpha [15,72] and endotoxin [69] can down-regulate TM and EPCR expression [32] on cultured endothelial cells."
10708869
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"The proinflammatory cytokine, TNF-alpha, downregulates the expression of thrombomodulin (TBM), and induces coagulation dysfunction."
34099346
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"In contrast, TNF-α significantly increased the amount of TF and significantly and dramatically reduced the level of TM, which resulted in the increased amount of thrombin in TGA."
38675220
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"On the contrary, the TNF-α treatment dramatically decreased the level of TM in HUVEC after 6 h both at mRNA and protein levels [33]."
38675220
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"Since TNF-alpha and IL-1 are known to downregulate endothelial expression of TM, this study investigated the effects of TNF-alpha on production of TM by the monocytic leukemic cell line, THP-1."
9594445
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"N. and Hancock, W.W. (1992) Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7561126
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"Moreover, TNFα downregulates TM expression and increased TF and plasminogen activator inhibitor-1 (PAI-1) expression."
35528838
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"In vitro, TNF-alpha downregulates the expression of thrombomodulin on endothelial cells leading to decreased protein C and protein S activity, thereby contributing to the procoagulant state [10]."
11772264
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"TNFalpha treatment attenuated TM expression in HAECs in a time dependent manner."
17211835
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"Suppression of endothelial thrombomodulin expression by TNF-alpha has been documented [XREF_BIBR]."
27408725
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"TNFalpha down-regulates TM expression and also activates IKKbeta."
25039491
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"Our previous studies demonstrated that TNF-alpha, an important inflammatory cytokine, also reduced TM mRNA levels."
16153429
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"We conclude that TNF acts primarily to inhibit thrombomodulin transcription."
1846763
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"The results in this report showed that TNF-alpha treatment decreases the expression of TM in keratinocytes when cultured in normal-glucose medium and that anti-TNF-alpha antibody rescues the decreased[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25651160
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"In the downstream events, TNF-alpha increased TF antigen and activity, and suppressed the expression of thrombomodulin (TM) antigen."
25162582
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"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells."
2854203
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"These data demonstrate that TNF-alpha significantly decreases expression of TM and EPCR at both mRNA and protein levels in several human endothelial cells."
15733976
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"TNFa and interleukin 1beta induce the expression of endothelial procoagulant activity (tissue factor) and simultaneously downregulate the expression of thrombomodulin, the endothelial surface high-aff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15925818
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"The results are partly consistent with known effects of cytokines such as TNF-alpha and interleukin-1, which activate the endothelium in vitro (Dustin and Springer, 1989), although TNF-alpha is report[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9543319
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"TNF-α downregulates transcription of thrombomodulin, with an in vivo study demonstrating >80% reduction in thrombomodulin levels after treatment with TNF-α (55, 56)."
34485349
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"Interestingly, it has been shown that TNF-α and LPS can downregulate TM expression on monocytes.Most studies on human peripheral blood monocytes showed decreased TM mRNA and surface expression upon LPS stimulation, similar to endothelial cells (9)."
39132505
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"Cyclic adenosine monophosphate stimulates TM expression in cultured SMC, but not EC, while tumor necrosis factor suppresses TM expression in EC but not cultured SMC."
1846762
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"In addition, TNF-α is also able to down-regulate the tissue factor pathway inhibitor mRNA [62] and reduce the glomerular expression of thrombomodulin, a constitutive anticoagulant glycoprotein of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17113815
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"32 TNF-alpha can down-regulate the expression of thrombomodulin on endothelial cells."
16522396
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"For example, radiation induced inflammatory cytokine (TNFalpha) or protease (granulocyte elastase) suppress TM transcription or cleave TM from the endothelial cell membrane to pass it into circulation [XREF_BIBR, XREF_BIBR]."
32164317
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"Silencing of MT1-MMP by siRNA also reversed the changed expression of TF and TM induced by TNF-alpha."
25162582
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"Simvastatin enhanced the expression of CD39 and thrombomodulin mRNA initially reduced by IL-17 and TNF-alpha combination."
22915623
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"Finally, immune hemolysis is accompanied by activation of the complement cascade and production of TNF-alpha, which induces tissue factor expression in endothelial cells and decreases the endothelial expression of thrombomodulin, down-regulating the anti-coagulant pathway [XREF_BIBR]."
30618125
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"These proinflammatory cytokines further drive excess endothelial cell TF expression, and TNF-α also decreases thrombomodulin transcription, leading to hypercoagulability and impaired regulation of coagulation [94,95,96,97,98]."
37444587
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"The mRNA levels of THBS1 and THBD were slightly downregulated by IL-17 or TNF-α alone and largely reduced by IL-17 plus TNF-α."
35844613
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"Tumor necrosis factor (TNF), a mediator of the inflammatory response, induces tissue factor and decreases the expression of thrombomodulin (TM) on endothelial cells, thus shifting the hemostatic properties of the endothelium."
2535943
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"In addition, TNF-alpha may decrease TM expression in endothelial cells (Nan et al., 2005)."
25651160
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"Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression."
9534204