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TNF decreases the amount of THBD. 31 / 34
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"32 TNF-alpha can down-regulate the expression of thrombomodulin on endothelial cells."
16522396
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"TNF suppresses transcription of the thrombomodulin gene in endothelial cells and may affect coagulation [XREF_BIBR]."
23459312
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"Oxidative stress (81), hypoxia (114), oxidized LDL (68), C-reactive protein (110), phorbolesters (PMA) (58), cyclic adenosine monophosphate (cAMP) (58), and TNF-α (58) tend to downregulate endothelial TM expression, while an upregulatory effect has been attributed to thrombin (136), VEGF (20), retinoic acid (97), and heat shock (50)."
23604713
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"TNF decreased HUVEC expression of THBD, and PROCR, and increased F3 levels while increasing TF and FIX production."
32029851
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"Suppression of endothelial thrombomodulin expression by TNF-alpha has been documented [XREF_BIBR]."
27408725
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"Finally, immune hemolysis is accompanied by activation of the complement cascade and production of TNF-alpha, which induces tissue factor expression in endothelial cells and decreases the endothelial expression of thrombomodulin, down-regulating the anti-coagulant pathway [XREF_BIBR]."
30618125
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"N. and Hancock, W.W. (1992) Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7561126
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"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells."
22682140
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"Endotoxin, IL-1beta and TNF-alpha inhibit the expression of thrombomodulin and the endothelial cell protein C receptor, thus reducing the formation of activated protein C and inhibiting its anticoagulant activity [XREF_BIBR, XREF_BIBR]."
28208708
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"ATA increased endothelial thrombomodulin expression that was downregulated by TNF-alpha or lipopolysaccharide, in a dose dependent manner."
18685431
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"The proinflammatory cytokine, TNF-alpha, downregulates the expression of thrombomodulin (TBM), and induces coagulation dysfunction."
34099346
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"IL-1 and tumor necrosis factor (TNF) induce changes in the hemostatic properties of endothelial cells surface which leads to increased tissue factor and decrease thrombomodulin expression and suppression of protein C activity."
10352499
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"TNFa and interleukin 1beta induce the expression of endothelial procoagulant activity (tissue factor) and simultaneously downregulate the expression of thrombomodulin, the endothelial surface high-aff[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15925818
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"Moreover, TNFα downregulates TM expression and increased TF and plasminogen activator inhibitor-1 (PAI-1) expression."
35528838
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"TNF alpha and other inflammatory mediators can down-regulate EPCR and TM and IL-6 can depress levels of protein S in experimental animals."
15063484
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"We conclude that TNF acts primarily to inhibit thrombomodulin transcription."
1846763
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"Simvastatin enhanced the expression of CD39 and thrombomodulin mRNA initially reduced by IL-17 and TNF-alpha combination."
22915623
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"We have previously reported that TNF-alpha decreases the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells [36]."
17949793
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"In addition, the expression of TM can be reduced by TNFα, IL-1β, and endotoxin, which cause proteolytic cleavage, internalization, and suppression of transcription (56)."
34490308
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"Thromobomodulin transgene expression driven by the enhanced PAI-1 promoter in rAAV vector transduced cultured endothelial cells was between 600- and 1000-fold higher than constitutive thrombomodulin gene expression in cultured human umbilical vein endothelial cells and was up-regulated by TGFbeta1 and TNFalpha stimulation which may down-regulate endogenous thrombomodulin gene expression in endothelial cells."
11892836
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"In the downstream events, TNF-alpha increased TF antigen and activity, and suppressed the expression of thrombomodulin (TM) antigen."
25162582
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"Tumor necrosis factor (TNF), a mediator of the inflammatory response, induces tissue factor and decreases the expression of thrombomodulin (TM) on endothelial cells, thus shifting the hemostatic properties of the endothelium."
2535943
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"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells."
2854203
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"TNF has also been shown to increase tissue factor procoagulant activity, enhance IL-1 and plasminogen activator inhibitor-1 and suppress expression of thrombomodulin as well as cofactor activity ofpro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8390056
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"Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression."
1309855
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"The results are partly consistent with known effects of cytokines such as TNF-alpha and interleukin-1, which activate the endothelium in vitro (Dustin and Springer, 1989), although TNF-alpha is report[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9543319
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"For example, TNF-α and IL-1β can induce the expression of TF by vascular endothelial cells and downregulate the expression of thrombomodulin, the surface receptor for thrombin leading to reduced activation of the protein C system, which is one of the main anticoagulant defence systems [14]."
34603868
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"Conversely, the expression levels of THBD and PROCR (gene for EPCR) are reduced by TNF ."
32029851
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"Tumor necrosis factor production during human renal allograft rejection is associated with depression of plasma protein C and free protein S levels and decreased intragraft thrombomodulin expression."
9534204
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"TNF-α downregulates transcription of thrombomodulin, with an in vivo study demonstrating >80% reduction in thrombomodulin levels after treatment with TNF-α (55, 56)."
34485349
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"Tumor necrosis factor (TNF)-alpha (50 ng/ml) or lipopolysaccharide (20 microg/ml) downregulated the expression of endothelial thrombomodulin."
18685431