IndraLab

Statements

UCHL1 inhibits TNF. 6 / 7
| 6
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"Over-expression of UCH-L1 inhibits TNFalpha mediated VSMC proliferation."
19945429
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"Overexpression of the UCHL1 gene significantly attenuated tumor necrosis factor (TNF)-alpha-induced NF-kappaB activity in vascular cells and increased inhibitor of kappa B-alpha (IkappaB-alpha), possibly through the attenuation of IkappaB-alpha ubiquitination, leading to decreased neointima in the balloon injured artery."
17690318
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"It worthy to note that UCH-L1 suppresses tumor necrosis factor alpha (TNFalpha) - rather than PDGF-BB-mediated activation of ERK and proliferation in vascular smooth muscle cells (VSMCs) XREF_BIBR."
24732420
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"An earlier report from our lab demonstrated that UCHL1 deubiquitination can itself negatively regulate TNFalpha mediated VSMC proliferation by suppressing Erk [XREF_BIBR]."
25342597
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"Besides, Ichikawa et al found that UCHL1 could negatively regulate TNFα-mediated vascular smooth muscle cell proliferation [43]."
30359286
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"Our results uncovered for the first time that UCH-L1 negatively regulates TNFalpha mediated VSMC proliferation via suppressing ERK activity."
19945429