IndraLab

Statements

UBE2O activates BAP1. 5 / 8
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"UBE2O-mediated ubiquitylation causes BAP1 to accumulate in the cytoplasm, whereas BAP1 autodeubiquitylation promotes nuclear retention."
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"The ubiquitin conjugating enzyme UBE2O induces BAP1 sequestration in the cytoplasm by multi monoubiquitylation of its nuclear localization signal (NLS)."
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"Indeed, the subcellular localization of BAP1 is coordinated by the E3 ligase UBE2O which promotes BAP1 cytoplasmic retention ."
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"The antagonistic relationship between UBE2O and BAP1 is also observed during adipogenesis, whereby UBE2O promotes differentiation and cytoplasmic localization of BAP1."
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"Of note, overexpression of UBE2O, but not its catalytic dead form, also promoted cytoplasmic localization of endogenous BAP1."
24703950