IndraLab

Statements

UBE2O activates BAP1. 6 / 9
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"Of note, overexpression of UBE2O, but not its catalytic dead form, also promoted cytoplasmic localization of endogenous BAP1."
24703950
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"UBE2O mediates BAP1 subcellular location."
37533513
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"Besides, the proteasome inhibitor MG132 cannot influence the UBE2O-mediated multimonoubiquitination pattern of BAP1 in 293T cells co-transfected with UBE2O and BAP1 or C91S mutant."
37533513
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"Indeed, the subcellular localization of BAP1 is coordinated by the E3 ligase UBE2O which promotes BAP1 cytoplasmic retention ."
30349006
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"UBE2O-mediated ubiquitylation causes BAP1 to accumulate in the cytoplasm, whereas BAP1 autodeubiquitylation promotes nuclear retention."
30030490
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"The ubiquitin conjugating enzyme UBE2O induces BAP1 sequestration in the cytoplasm by multi monoubiquitylation of its nuclear localization signal (NLS)."
28614305