IndraLab

Statements

L-prolylglycine inhibits NLRP3. 11 / 11
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"Some researchers have found that PG can significantly inhibit the activation of NLRP3 inflammatory corpuscles induced by Aβ, suggesting that the neuroprotective mechanism of NLRP3-caspase-1 inflammatory corpuscles regulated by PG may be a potential therapeutic target to improve the pathophysiological process of AD[15]."
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"PG resisted N. caninum infection by regulating NLRP3 inflammasome pathway."
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"Pg + ATP downregulated NLRP3 , ASC , POP1 , but upregulated IL-1beta and CARD16 ."
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"ROS inducer PG inhibited N. caninum replication by promoting NLRP3 inflammasome activation in vitro."
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"These results show that ROS mediated NLRP3 dependent inflammasome activation plays a key role in controlling N. caninum infection, and the PG can inhibit parasite replication in N. caninum infected PMs mainly by promoting NLRP3 inflammasome activation and other mechanism."
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"PG blocked CM-triggered TLR4-P2X7r/NLRP3 activation in A549, with similar functioning as A438079."
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"To further explore the role of PG induced NLRP3 inflammasome activation in inhibiting N. caninum infection in vivo, WT and Nlrp3 -/- mice were infected with N. caninum and then treated with PG."
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"The present study shows that PG can prevent the DIC by improving the DOX-induced vitality, repairing the myocardial damage, and inhibiting the NLRP3 inflammasome-related pyroptosis."
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"Proteolysis of the NLRP3 protein was not observed with heat killed Pg and inhibition of ECs protein synthesis with cycloheximide did not abolish the NLRP3 protein degradation induced by Pg infection in ATP pre-treated cells."
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"Relative to the DOX group, the PG treatment significantly decreased the DOX-induced upregulation of oligomerized ASC, NLRP3, cleaved-CASP1 (cl-CASP1), and GSDMD-N."
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"Treatment of the monocytes with PG or VD showed that these hormones negatively regulate monocyte endogenous activation from preeclamptic women by decreasing the activation of NLRP1/NLRP3 inflammasome [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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