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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 inhibits POT1. 3 / 3

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"TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7 Dependent Proteasomal Degradation of POT1."

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"In the absence of TSPYL5, USP7 can freely degrade POT1, triggering telomere dysfunction and inducing cell death (Fig. 3)."

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"TSPYL5 interacts with POT1 sequestered within APBs which may protect against USP7-mediated degradation of POT1."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP7 inhibits POT1. 3 / 3

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