IndraLab

Statements

USP7 inhibits POT1. 4 / 4
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"Interestingly death of ALT positive cells occurred due to depletion of TSPYL5 which in turn activate USP7-dependent proteasomal degradation of POT1 (component of shelterin complex)."
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"Peptidase USP7 and ubiquitin ligase SIAH1 activate proteasomal degradation of POT1 and TERF2, respectively (Codd et al., 2021)."
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"TSPYL5 interacts with POT1 sequestered within APBs which may protect against USP7-mediated degradation of POT1."
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"In the absence of TSPYL5, USP7 can freely degrade POT1, triggering telomere dysfunction and inducing cell death (Fig. 3)."
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