IndraLab

Statements

USP7 activates Neoplasms. 14 / 15
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"Pharmacological inhibition of USP7 significantly suppressed tumor growth in both xenograft and PDX models."
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"Moreover , USP7 promotes tumor progression by deubiquitinating and stabilizing the histone demethylase PHF8 and by upregulating cyclin A2 in breast cancer ( Wang et al. 2016 ) ."
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"Together, our findings indicate that FOXM1 is a major target of USP7 in modulating tumor growth in a p53-independent manner and reveals the USP7 degrader as a potential therapeutic tool for the treatment of triple-negative breast cancers."
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"These findings have shown that USP7 may induce tumour progression and be a therapeutic target ."
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"Although numerous studies indicate that inhibition of USP7 suppresses tumor growth by activating p53, the precise mechanism by which USP7 contributes to tumor growth through the p53-independent manner is not well understood."
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"Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1."
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"USP7 was also shown to promote cancer by stabilizing beta-catenin and inducing signaling regulating cell fate determination and migration via the Wnt pathway [ 107 ] ."
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"USP7 exhibits a high expression signature in various malignant tumors, and increased USP7 expression often indicates the poor tumor prognosis, suggesting that USP7 is a marker of tumor prognosis and a potential drug target for anti-tumor therapy."
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"USP7 inhibitors likewise inhibit tumor proliferation and promote PD-1 / PD-L1 expression and immune response ( 31 ) ."
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"Here, we show in vivo that deletion of Usp7 in Apc-truncated mice inhibits crypt hyperproliferation and intestinal tumor development."
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"A high USP7 expression may promote cancer progression and predict unfavourable prognosis of cancer patients , especially those with EOC ."
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"USP7 promoted cell proliferation, migration, invasion in vitro and tumor growth by stabilizing TAZ."
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"This theory’s generality is also manifested in the fact that targeting USP7 can help enhance tumor response to multiple therapeutic strategies, including traditional chemotherapy, molecular targeted therapy, immunotherapy, and radiation therapy."
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"Further , we found that USP7 inhibitor inhibited tumor proliferation via promoting the stability of P53 in GC and arrested the cell cycle at G2-M phase ."
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