IndraLab

Statements

BAP1 activates H2AK119ub. 6 / 6
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"Such as, the mutant ASXL1 (ASXL1-MT)/BAP1 complex can impair the multidirectional differentiation of HSPCs (except to monocytes) and promote RUNX1-ETO-induced murine c-Kit+ progenitor cell leukemogenesis by removing H2AK119ub, which drives the upregulation of the HOXA gene and interferon regulatory factor 8 (IRF8) [135]."
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"In line with our results using murine 32Dcl3 cells, ASXL1-MT was associated with global reduction of H2AK119ub, which was dramatically enhanced by the coexpression of BAP1."
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"32Dcl3 cells expressing ASXL1-MT showed global reduction of H2AK119ub, which was dramatically enhanced by the coexpression of BAP1, but not by that of BAP1-C91S."
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"Expression of ASXL1-WT showed no effect on global reduction of H2AK119ub, which was only slightly enhanced by the coexpression of BAP1."
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"Moreover, BAP1 depletion also abrogated the global reduction of H2AK119ub induced by ASXL1-MT."
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"H2AK119ub is associated with chromatin compaction and gene repression.61 Truncated ASXL1 strengthens its interaction with BAP1, which enhances removal of H2AK119ub."
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