IndraLab

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NOTCH1 activates USP11. 2 / 2
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"Taken together, we demonstrate transcriptional activation of USP11 by NOTCH1 in T-ALL.We then hypothesized that USP11 might control NOTCH1 protein levels through deubiquitination based on the positive correlation between USP11 and NOTCH1 protein expression and the deubiquitinating activity of USP11."
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"Overexpression of NIC in each GIC reduced USP11 and PML (XREF_FIG), whereas gamma-secretase inhibitor or Notch1 siRNA increased USP11 and PML (XREF_FIG)."
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