IndraLab

Statements

USP28 inhibits cell population proliferation. 16 / 16
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"Downregulating USP28 expression can inhibit the proliferation and growth of lung cancer cells [XREF_BIBR, XREF_BIBR]."
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"Deubiquitinases have potential deep clinical impacts as is the case of USP28, that when overexpressed, may inhibit AML proliferation and sensitizes AML to the hypomethylating agent azacytidine [ 23 ],[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP28 depletion significantly increased the proliferation rate and strikingly delayed senescence (Fig. 2A–C; Supplemental Fig. S3A)."
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"LncRNA-SNHG14/miRNA-3940-5p/NAP12 mRNA may be potential for CRC diagnosis and prognosis.8 miR-3940-5p negatively regulates CUL7 and activates NF-κB to promote gliomagenesis in human gliomas.38 miR-3940-5p targets CCND1 and USP28 to inhibit proliferation and induce apoptosis in NSCLC cells."
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"CCK8 and EdU assay showed that si-USP28 reduced PASMCs proliferation ( Fig. 4 A and B)."
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"Conversely, USP28 downregulation may significantly inhibit the proliferation and migration of GC cells; however, the effects of USP28 expression on the proliferation and migration of gastric epithelial mucosal cell lines were not significant (46)."
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"Functional experiments showed that down-regulation of USP28 expression effectively inhibited the proliferation, migration and invasion of HCC cells, while overexpression of USP28 produced the opposite effect."
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"Additionally, according to the study by Popov, et al., depletion of USP28 in HeLa and LS174T cells can inhibit cell growth and proliferation due to its inability to enhance c-Myc stability [XREF_BIBR]."
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"Recently, it was shown that loss of USP28 or 53BP1, two upstream components of MSP, can rescue NPC proliferation in microcephaly models with centrosome defects (Phan et al. 2021)."
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"CCK-8 assay shows that si-CCND1 and si-USP28 significantly inhibit A549 cell proliferation compared with si-controls (XREF_FIG, E and F)."
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"MTT assays showed that USP28 overexpression reduced cell proliferation in MDA-MB-231 and MCF7 cells, and these effects were partially reversed by transfection with miR-500a-5p mimics."
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"miR-3940-5p can target CCND1 and USP28 to inhibit the growth of NSCLC cells, and overexpression of CCND1 and USP28 can attenuate miR-3940-5P-induced proliferation and apoptosis of NSCLC cells (88)."
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"Importantly, silencing KLHL2 or USP28 overexpression not only inhibited AML cell proliferation but also sensitized AML cells to 5 '-AZA-induced apoptosis in vitro and in vivo."
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"Downregulation of CCND1 and USP28 Inhibits Proliferation and Induces Apoptosis in A549 Cells."
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"Similarly, a study proposed the existence of a “stopwatch” composed of USP28, 53BP1, and p53 that limits the proliferation of daughter cells that arise after a prolonged mitosis (Meitinger et al. 2016)."
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"Moreover, 53BP1 or USP28 deletion restored NPC proliferation and brain size without correcting the upstream centrosome defects or extended mitosis."
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