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BAP1 activates H2AK119ub1. 2 / 2

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"In human tumors, H2AK119ub1 deposition is enhanced by frequent inactivating mutations of the H2AK119ub1-specific deubiquitinase BAP1 (Carbone et al., 2013)."

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"BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation."

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IndraLab

Statements

BAP1 activates H2AK119ub1. 2 / 2

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