IndraLab
Statements
Ondansetron inhibits KCNH2. 2 / 5
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"IKr Is Inhibited by Dofetilide and Ondansetron But Not by AP14145 We have previously shown that the IC50 of AP14145 on Kv11.1 was : 71.8 muM ( Diness et al ., 2017 ) , and in this study we confirm that dofetilide , which is a known Kv11.1 blocker , has an IC50 = 0.03 muM ( n = 14 ) while ondansetron blocks Kv11.1 with an IC50 = 2.79 + / - 0.03 muM ( n = 6 , Figure 5 ) ."