IndraLab

Statements

USP11 activates TGFB. 18 / 21
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"USP11, a ubiquitous protein in various human cells, has been shown to enhance TGFbeta receptor (ALK5) stability and regulate DNA repair."
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"While wild-type (wt) USP11 significantly enhanced TGFbeta induced transcriptional reporter activity, the catalytically inactive mutant USP11 (C318S) had no effect (see XREF_FIG d and the electronic supplementary material, figure S3)."
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"Ubiquitin-specific peptidase 11 (USP11) has been reported to promote transforming growth factor β (TGFβ) signaling which plays essential role underlying RIPF."
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"Despite its interaction with SMAD7, we found that USP11 enhanced TGFbeta signalling and bound the TGFbeta R1 receptor (ALK5)."
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"USP11 overexpression in T EFF cells enhanced the activation of the TGF-beta pathway and promoted T REG or T H 17, but not Th1, cell differentiation in vitro and in vivo, an effect abrogated by USP11 gene silencing or the inhibition of enzymatic activity."
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"USP11 knockdown inhibits TGFbeta pathway signalling."
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"The DUBs USP4, USP11, USP15, and UCH37 have previously been demonstrated to modulate TGF-beta pathway activity by directly deubiquitinating the TbetaRI, resulting in increased TbetaRI stability (XREF_FIG) XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
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"High levels of USP11 have been detected in lung tissues from patients with IPF and bleomycin-induced mice , whereas inhibition of USP11 expression attenuates TGF-beta signaling ( 57 ) ."
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"USP11 Enhances TGFbeta Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis."
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"USP11 enhances TGFbeta pathway signalling."
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"USP11 promotes TGF-beta signaling by deubiquitinating the TbetaRI ALK5 through interaction with and recruitment via SMAD7 [ 30 ] ."
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"Ubiquitin-specific peptidase 11 ( USP11 ) has been reported to promote transforming growth factor beta ( TGFbeta ) signaling which plays essential role underlying RIPF ."
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"This result indicates a central role for the proteasome in USP11 modulation of TGFbeta pathway signalling."
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"The deubiquitylase activity of USP11 is required to enhance TGFbeta induced gene transcription."
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"We have previously reported that USP11, which interacts with both SMAD6 and SMAD7, enhances TGFbeta signalling through ALK5 deubiquitylation [XREF_BIBR]."
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"USP11 enhances TGFbeta signalling and can override the negative effects of SMAD7."
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"High levels of USP11 have been detected in lung tissues from patients with IPF and bleomycin-induced mice, whereas inhibition of USP11 expression attenuates TGF-β signaling (57)."
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"Thus, USP11 potentiates TGF-beta signaling in both T REG and T EFF cells, in turn driving increased suppressive function and lineage commitment in thymic derived T REG cells and potentiating the TGF-beta-dependent differentiation of T EFF cells to peripherally induced T REG and T H 17 cells."
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