IndraLab

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3',5'-cyclic AMP activates HCN4. 24 / 25
| 2 22
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"HCN4 channels constitutively activated by basal intracellular cAMP production in bladder may serve as an effective therapeutic target for disorders affecting detrusor contractility such as OAB without any cardiac effects."
26709376
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"Because intracellular cAMP reportedly activates HCN2 and HCN4 channels by shifting the voltage dependence of the activation curve [XREF_BIBR], HCN4 channels expressed in PKCgamma-IR interneurons may be activated by partial sciatic nerve ligation via an increase in cAMP."
| PMC
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"Intracellular cAMP positively modulates the gating of the HCN2 and HCN4 isoforms resulting in a shift of the activation curve by 15-20 mV in the positive direction."
25580535
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"The effect of adenosine on HCN cation current I h seems to involve the activation of adenylyl cyclase and the increase in intracellular cAMP that in turn activates HCN4 containing non selective cation channels that mediate I h."
29311923
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"Whereas the cAMP sensitivity of HCN1 and HCN3 is low, HCN2 and HCN4 are strongly modulated by cAMP [XREF_BIBR]."
22694806
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"Cyclic AMP (cAMP) enhances the activity of HCN2 and HCN4 isoforms by shifting the voltage dependence of activation to more depolarized potentials, whereas HCN1 and HCN3 isoforms are practically insensitive to this ligand."
29980633
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"For instance, it has been shown that in Chinese hamster ovary (CHO) cells external application of cAMP did not increase HCN4 channel activity in both whole-cell recordings and excised patches as the basal voltage dependence was already shifted to more depolarized potentials [XREF_BIBR]."
28950029
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"Second, the HCN2 and HCN4 channels are modulated by an increase in cAMP, with the midpoint of the voltage-activation curve shifted in the positive direction by 12–20 mV, whereas the HCN1 and HCN3 channels show little sensitivity to cAMP."
| PMC
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"Since β‐adrenergic signaling increases the production of cAMP which enhances gating of Hcn4 ion channels as well as intracellular Ca cycling,41, 42 it is unclear what molecular determinants are responsible for the contrasting effects of isoproterenol treatment (Figure 6b, (i)–(iii))."
31763140
eidos
"HCN2 and HCN4 are modulated by cAMP and PKA , which might be selectively targeted [ 311 ] ."
33063247
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"Here, we utilize comparative S672R versus WT NMR analyses to show that the S672R mutation results in extensive perturbations of the dynamics in both apo- and holo-forms of the HCN4 isoform, reflecting how S672R remodels the free energy landscape for the modulation of HCN4 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels."
28174302
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"The mHCN2-h4 channel reproduced key features of cAMP modulation of HCN4 channels."
23217679
eidos
"Specifically , cAMP-dependent increase of HCN4-mediated current was believed to be required for the acceleration of the HR upon high activity of the sympathetic division of the ANS , whereas a drop in cAMP levels following vagal stimulation would decrease HCN4 activity and slow down the HR5 ,6,9 ."
33144559
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"Alternatively, since HCN4 currents are modulated by cAMP [XREF_BIBR], activators of stimulatory and inhibitory G-proteins could affect HCN4 inward currents and regulate sour taste cell activation [XREF_BIBR, XREF_BIBR]."
19284629
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"To address this possibility, we first confirmed that cAMP can bind to the isolated CNBD of HCN4 (as suggested by the elimination of cAMP modulation of HCN4 in HEK cells by the R669Q mutation; XREF_FIG)."
23109717
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"The cAMP dependent activation of HCN4 channels appeared to enhance this protective effect, rather than expediting sympathetic response of the SAN."
29315578
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"Intracellular cAMP promotes activation of the HCN4 and HCN2 isoforms, while HCN1 and HCN3 are relatively insensitive to cAMP."
31290157
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"Cyclic AMP (cAMP) enhances the activity of HCN2 and HCN4 isoforms by shifting the voltage dependence of activation to more depolarized potentials, whereas HCN1 and HCN3 isoforms are practically insensitive to this ligand."
29980633
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"An increase of cAMP has been known to activate HCN2 and HCN4 channels by directly binding in a reversible way to the intracellular cyclic nucleotide-binding domain [5,18]."
| PMC
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"HCN2 and the HCN4 isoforms (Ludwig et al., 2003; Notomi and Shigemoto, 2004) are strongly modulated by cAMP in thalamocortical (TC) relay neurons (Kanyshkova et al., 2009, 2012)."
30405353
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"Coassembly of PEX5R and Trip8b affects HCN channel gating in a subtype dependent and mode specific way : activation of HCN2 and HCN4 by cAMP is largely impaired, while gating by phosphoinositides and basal voltage-dependence remain unaffected."
19555650
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"Although HCN4 channels are activated by cAMP, the sympathetic response of the SAN was preserved in patients carrying loss-of-function mutations of the HCN4 gene."
29315578
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"CAMP potentiates voltage dependent gating of HCN4 channels either by binding directly to a conserved cyclic nucleotide binding domain in the proximal C-terminus [XREF_BIBR, XREF_BIBR] or by protein kinase A (PKA)-mediated phosphorylation of the distal C-terminus [XREF_BIBR]."
28868308
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"Of the four different isoforms of HCN channels found in vertebrates (HCN1-4), HCN2 and HCN4 are strongly stimulated by cAMP, in contrast to HCN1 and HCN3."
29980633