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UCHL1 activates Neoplasm Invasiveness. 53 / 54
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"Furthermore, Scratch assay and Transwell assay proved that UCHL1 enhanced the migration and invasion of TNBC cells."
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"Furthermore, mutations in UCHL1 could elevate oxidative stress, resulting in apoptosis, similar to what is observed in neuronal cells.Several studies have demonstrated that the activation of UCHL1 promotes cancer cell invasion by activating various signaling pathways, including mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3-kinase/protein kinase B (AKT), involved in tumorigenesis of different types of cancer [13,21,23,29-32]."
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"Knocking down NOX4 in B16F10 cells significantly reduced both basal and UCH-L1 enhanced invasiveness of cells, suggesting that both inherent and UCH-L1-enhanced invasiveness of B16F10 cells depend on NOX4."
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"Here we show that the remodelling process is regulated by the ubiquitin C-terminal hydrolase UCH-L1 that promotes the invasion of epithelial cells by Listeria monocytogenes and Salmonella enterica."
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"51 Finally, UCHL1 and EZR are believed to enhance invasion."
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"UCHL1 induces EMT, and thus enhances the migration and invasion processes in metastatic prostate cell lines [116]."
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"In non small lung cancer cell line H157, UCHL1 promotes invasion by upstream activation of Akt XREF_BIBR."
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"To investigate the invasion-promoting function of UCHL1 in osteosarcoma cells, the invasion capacity of MG63 and Saos2 cells was evaluated by transwell assay."
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"On the other hand, UCHL1 acts as an oncogenic factor via PI3K/Akt, MAPK/Erk, and other signaling pathways to promote the development, invasion, and metastasis of breast cancer as well as NSCLC, lymphoma, osteosarcoma, and neuroblastoma [147]."
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"However, two other studies reported higher UCHL1 expression in liver metastases from GC and gastric cardiac adenocarcinoma, likely because UCHL1 overexpression increases the proliferation, migration, and invasion capabilities of GC cells [83,84]."
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"UCHL1 is a key promoter of cell invasion and metastasis in small cell lung cancer but not necessarily required for cell viability or proliferation [XREF_BIBR, XREF_BIBR]."
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"Migration and invasion of SCNEC tumor cells were induced by UCHL1 over-expression and suppressed by UCHL1 down-regulation, as shown by scratch and transwell invasion assays."
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"Although our results point to a pivotal role for UCHL1 in stimulating breast cancer extravasation by regulating TGFbeta signaling , we do not preclude that UCHL1 may also promote invasion and metastasis by targeting other signaling proteins ."
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"In our study, reduction of the UCHL1 expression in MG63 cells by treatment with specific shRNA decreased their invasion capability, while over-expression of UCHL1 in Saos2 cells significantly promoted[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further in vivo tumor formation study in nude mice indicated that knockdown of UCHL1 in osteosarcoma cells reduced the progress of tumor formation.Moreover, it has been shown that UCHL1 promotes cell [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Transfection of UCHL1 substantially promoted cell invasion under 3D culture conditions, while treatment with LDN57444 eliminated this increase (Figure 3D)."
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"Recently, UCH-L1 has been known to enhance tumor cell invasion and migration capability via the Akt mediated pathway [53]."
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"Recently, it has been suggested that UCH-L1 promotes cancer cell motility and invasion, which may contribute to its oncogenic role."
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"The invasion of NSCLC cells is enhanced due to activation of the Akt signaling pathway by UCH-L1 (Fig. 6) (33)."
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"UCH-L1 stimulates prostate cancer cell migration and invasion as well by promoting epithelial-to-mesenchymal transition (EMT) [XREF_BIBR]."
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"Overexpression of WT UCHL1 in prostate adenocarcinoma cells promoted migration and invasion, whereas loss of UCHL1 in NEPC cells significantly reduced migration and invasion in vitro (Figures S3A‒S3C)."
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"In lung adenocarcinoma , UCHL1 promotes tumor migration , invasion , and metastasis by inhibiting apoptosis and has an important impact on the clinical drug treatment of lung adenocarcinoma ."
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"These findings indicate that H 2 O 2 levels regulated by UCH-L1 are necessary for cell invasion to occur and demonstrate that UCH-L1 promotes cell invasion by up-regulating H 2 O 2 via deubiquitination of NOX4."
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"These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt and Erk1/2, which may account for its higher positive expression rate in liver metastases from gastric cancer."
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"Subsequently, it has been established that UCH-L1 overexpression further enhances metastasis or invasiveness of cells by altering cancer cell morphology and regulating the Akt signaling pathway (85)."
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"Higher expression of ubiquitin C-terminal hydrolase-L1 (UCHL1) in liver metastasis than in primary tissue could activate the ERK1/2 signaling, thus promoting the proliferation, migration, and invasion of GC cells (55)."
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"Overexpression of UCHL1 in MKN45 and BGC823 cells promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity."
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"These results demonstrate that UCH-L1 overexpression leads to enhanced H 2 O 2 generation, and that invasion induced by UCH-L1 is reduced by eliminating H 2 O 2, suggesting that UCH-L1 plays a role in the regulation of H 2 O 2 generation."
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"Moreover, cell scratch assay and Transwell assays were performed to explore whether UCHL1 promotes the migration and invasion of TNBC cells."
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"These results suggest that UCH-L1 does not affect cell growth and proliferation in prostate cancer cells.In non-small lung cancer cells, UCH-L1 increases cancer cell invasion and metastasis by changin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, these findings demonstrated that UCH-L1 promotes invasion of breast cancer cells and might serve as a potential therapeutic target for treatment of human patients with breast cancers."
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"The potential role for UCHL1 in promoting breast cancer invasion and metastasis was further supported in a murine breast cancer xenograft model, where UCHL1 overexpressing groups exhibited increased metastasis compared to UCHL1 knockdown groups.To explore the mechanism of action by which UCHL1 promotes breast cancer metastasis, Liu et al. [54] investigated UCHL1 depletion in epithelial–mesenchymal transition (EMT), which has previously been shown to play an important role in breast cancer metastasis [55]."
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"Specifically, in gastric cancer, it has been revealed that overexpression of UCHL1 increases cell proliferation, migration, and invasion by activating the AKT and ERK1/2 tumor growth pathways, a phenomenon dependent on the enzymatic activity of UCHL1 (Gu et al., 2015)."
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"Consistent with the other results, UCH-L1 C90S did not increase the cell migration and invasion of RWPE1 cells in all assays.These results support the idea that the migratory and invasive behavior of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the present study, we found that UCH-L1 promotes prostate cancer cell invasion and metastasis by reducing cell–cell adhesion and EMT induction."
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"UCHL1 is highly expressed in non-small lung cancer cell line H157 and promotes invasion via activating the upstream Akt [19] ."
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"Moreover, we found that UCHL1 can promote the migration and invasion of tumor cells in the functional gene knockout experiment and has an important impact on the clinical drug treatment of lung adenocarcinoma."
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"It has been shown that silencing of UCH-L1 reduces invasion potential in breast cancer cells ( Jin et al., 2015 ; Ning et al., 2017 )."
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"In the Transwell and wound healing assays, we found that knockdown of UCHL1 significantly reduced cell migration, motility, and invasiveness."
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"Knockdown of UCHL1 inhibited lung adenocarcinoma cells migration and invasion."
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"UCHL1 might promote SCNEC cell migration and invasion by reducing PROX1 ubiquitination ."
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"Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result."
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"Complementarily, overexpression of UCHL1 enhanced invasion through Matrigel in M10 breast cells."
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"We have further demonstrated that knockdown of UCHL1 decreased cell migration and invasion in a manner that was concomitant with less pseudopod formation in a 3D collagen matrix and significantly redu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, it has been shown that suppression of UCHL1 inhibits the expression of genes involved in migration in HEK 293 T cells [1] and that UCHL1 enhances invasion in prostate cancer cells through EM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In our previous report, we demonstrated that UCH-L1 promotes prostate cancer cell migration and invasion through EMT induction [11]."
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"Through executing loss of function tests, we affirmed that silencing of UCHL1 expression significantly inhibited migration and invasion of lung adenocarcinoma cells in vitro."
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"In lung adenocarcinoma, UCHL1 promotes tumor migration, invasion, and metastasis by inhibiting apoptosis and has an important impact on the clinical drug treatment of lung adenocarcinoma."
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"Considering the recently established functional role of extracellular vesicles (ECV) in cancer progression, we suggest that specific inhibition of C-terminal farnesylation of UCH-L1 may reduce invasion and metastasis of EBV associated LMP1 positive metastatic carcinomas."
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"UCHL1 up-regulates beta-catenin signaling and possibly promotes invasion of both Salmonella and Listeria by modulating actin dynamics in the host cell."
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"Our loss of function studies using these pediatric high-grade gliomas cell lines showed that UCHL1 promoted cell growth, invasiveness, and self-renewal characteristics in vitro."
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"UCHL1 promotes in vitro clonogenicity, cell proliferation, and invasion."
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"We propose that C-terminal farnesylation of UCH-L1 facilitates LMP1 loading in exosomes and might promote tumor invasion and metastasis through modulating the cancer microenvironment."
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