IndraLab

Statements

FBXW7-185aa binds USP28. 4 / 4
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"XREF_BIBR Mechanistic studies demonstrated that FBXW7-185aa competitively interacted with the deubiquitinating enzyme USP28, preventing USP28 from binding to FBXW7, thereby upregulating FBXW7 expression."
33425494
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"The above evidence collectively elucidates that FBXW7-185aa competitively interacted with USP28 and " freed " FBXW7alpha to degrade c-Myc."
28903484
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"Instead, FBXW7-185aa binds to USP28, which is a de-ubiquitinating enzyme that stabilizes c-Myc by inhibiting FBXW7alpha activity."
28903484
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"Moreover, FBXW7-185aa can competitively bind USP28 to antagonizing USP28-induced c-Myc stabilization, thus suppressing glioma cell proliferation and cell cycle [74] ."
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