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USP7 inhibits BCL2. 2 / 2

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"As p53 can antagonize the anti-apoptotic effects of Bcl-2 and Bcl-xL [XREF_BIBR], USP7 may inhibit the Bcl-2 and Bcl-xL anti-apoptotic effect by negatively regulating p53."

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"Importantly, PARP cleavage and Bcl-2 downregulation induced by USP7 inhibition were attenuated upon ERα overexpression ( Fig. 7 C)."

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USP7 inhibits BCL2. 2 / 2

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