IndraLab

Statements

TNFAIP3 binds ITCH and CYLD. 3 / 3
| 3
sparser
"A20 and Cyld can form independent complexes with Itch to disassemble K63 chains and to add K48 polyubiquitination ( xref , xref )."
31515257
sparser
"Both A20 and Cyld can independently associate with Itch and Cyld interacts with Cbl-b to facilitate the removal of K63 polyubiquitin chains and to add K48 polyubiquitination ( xref , xref , xref )."
31515257
sparser
"DUB-E3 interactions are used for mutual ubiquitin-dependent regulation (e.g., to control each other’s stability, see above) or for editing ubiquitin chain architecture on particular substrates (as shown for the hybrid DUB/E3 enzyme A20 and CYLD-ITCH complexes during inflammatory signaling [ xref , xref ])."
33335288