IndraLab

Statements


TNF increases the amount of AQP1. 4 / 4
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"However, our data showed that TNF-alpha treatment strongly modulates AQP1 expression in B6-RPE07 cells in vitro."

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"We found that TNF-alpha induced a dose dependent down-regulation of AQP1 expression (P < 0.01) at mRNA (XREF_FIG) and protein level (XREF_FIG) and a dramatic decrease in AQP5 gene expression level (about 80% of control) with all the used doses (P < 0.001) (XREF_FIG), paralleled by a comparable trend at protein level (XREF_FIG)."

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"Suppression of AQP1 transcription by inflammatory TNF-alpha is restrained by KLF2."

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"Results of AQP1 and AQP5 determination found that HBO and TNF-alpha antagonist would upregulate the expression of AQP1 and AQP5 which was inhibited in rats with ALI."