IndraLab

Statements

NAD(+) inhibits NLRP3. 5 / 5
| 5
reach
"Stimulation of the P2X purinoceptor 7 (P2X7) by ATP release from damaged cells or by E. coli bacterial endotoxin also activates NLRP3 in monocytes/macrophages [14], while Sirtuin 2 (SIRT2), a class III nicotinamide adenine dinucleotide-dependent deacetylase ubiquitously expressed in cellular nuclei and cytoplasm [15], can prevent acetylation-dependent activation of the NLRP3 inflammasome under conditions such as aging and nutrient overload [16,17]."
38132466
reach
"Furthermore, we also show that NAD + -induced mitophagy inhibited NLRP3 inflammasome activation in the 3xTgAD mice."
31812486
reach
"In line with the reduction of ASC specks, paclitaxel augmented NLRP3 inflammasome activation was also inhibited by resveratrol, NAD +, or MEC-17 siRNA knockdown."
30761140
reach
"Furthermore, nicotinamide adenine dinucleotide can activate autophagy and inhibit the NLRP3 inflammasome to alleviate EAE [ 16 ]."
34384953
reach
"Moreover, the use of nicotinamide adenine dinucleotide (NAD ) in COVID-19 and viral infections in general has been shown to suppress NF-κB and NLRP3 inflammasome activity."
36851614