IndraLab

Statements

KCNA3 inhibits cell population proliferation. 9 / 9
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"Accordingly, the membrane potential control and proliferation of T EM is sensitive to Kv1.3 inhibitors whereas other T cells (naïve and central memory T cells) escape Kv1.3 blocker-induced inhibition [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these results reveal that lncRNA kcna3 inhibits cell proliferation and tumorigenesis through down-regulating YAP1 expression.A tremendous advance in lncRNAs research has been acquired [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, up-regulation of lncRNA kcna3 repressed the proliferation, migration, invasion and tumorigenesis of colon cancer SW620 cells.Furthermore, we observed that YAP1 expression was reduced and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Blockade of Kv1.3 by the most specific toxin inhibitor; Shk blunted the activation-induced proliferation of malignant T cells in Sezary syndrome, which express high levels of functional Kv1.3 [17]."
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"It is noteworthy that the expression of Kv1.3 has been shown to vary with the tumor stage and downregulation of Kv1.3 may significantly inhibit cell proliferation and increase cell apoptosis (77)."
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"Furthermore, while Kv1.3 gene silencing also significantly inhibited the increased proliferation of ox-LDL-treated VSMCs ( P < 0.01, P < 0.05 and P < 0.05), LY2784544 did not further reduce proliferat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that Granzyme B released by CD8 + T cells could inhibit NSCs proliferation, which relied mainly on voltage-dependent potassium channel, Kv1.3 in NSCs [55] ."
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"Inhibition of Kv1.3 with toxin peptides from natural toxic animals has been shown to suppress cytokine production, inhibit the proliferation of TEM cells, and ameliorate disease manifestation ( Carney[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been demonstrated that genetic silencing of neuronal Kv1.3 reduces neuronal death [17], and pharmacological blockade of Kv1.3 channels on neural progenitor cells promotes their proliferation [18]."
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