IndraLab

Statements

CUL4B activates COPS5. 3 / 4
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"X linked intellectual disability gene CUL4B targets Jab1 and CSN5 for degradation and regulates bone morphogenetic protein signaling."
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"As expected, silencing of both CUL4B and Jab1 decreased Jab1 immunofluorescence signals and increased Smad7 signals to levels almost equal to those observed in control RNAi treated cells."
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"Consistent with the results shown in Fig. 1 A and B, the transfection of pFLAG-CUL4B could almost completely rescue the BMP signaling in RNAi mediated CUL4B depletion cells, whereas FLAG-CUL4A or FLAG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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