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Lig4-4 inhibits KCNK2. 4 / 4
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"We find in the present study that lig4-4 can potently inhibit TREK-1 currents, enhance cell viability and reduces cell apoptosis in cultured neurons during OGD induced injury."
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"According to these results, a possible speculation is that lig4-4 inhibited TREK-1 and reduced K + efflux, therefore, depressed the process of cell apoptosis and resulted in up-regulation of Bcl-2 and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although lig4-4 was more potent to block TREK-1 than block other channels, we could not exclude the neuroprotective roles of lig4-4 through other ion channels.Previous studies demonstrated a connectio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In conclusion, we demonstrated that lig4-4 selectively inhibited TREK-1 and protected brain from cerebral ischemic injury."
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