IndraLab

Statements

Pirfenidone inhibits NLRP3. 10 / 10
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"In addition, pirfenidone used for the treatment of IPF may reduce CRP by antagonizing NOD-like receptor protein 3 (NLRP3) [33–35]."
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"Another agent, pirfenidone, was also reported to block the activation of the NLRP3 inflammasome to attenuate LPS-induced ALI."
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"In a mouse model of lipopolysaccharide-induced ALI, pirfenidone has been shown to reduce both inflammation and fibrosis by blocking the activation of the NLRP3 inflammasome."
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"Pirfenidone might also inhibit the formation of the NLRP3 inflammasome, a protein complex responsible for the recognition of stress signals and involved in the onset and maintenance of inflammation [ [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pirfenidone, an approved drug for the treatment of idiopathic pulmonary fibrosis, could inhibit the assembly of NLRP3 inflammasome and alleviate lung inflammation and the duration of hospital stay in COVID-19 patients (202)."
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"Our results showed that 0.4 mg/ml pirfenidone blocked silica-induced upregulation of NLRP3 and active caspase-1 p10 subunit."
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"Pirfenidone also blocks NLRP3 inflammasome activation, it ameliorates lipopolysaccharide induced inflammation and fibrosis."
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"In consideration of the effect of the inflammasome in cardiac fibrosis, Chinese herbal medicine triptolide and active small molecule pirfenidone have been used to treat fibrosis and were shown to inhibit NLRP3 inflammasome activity, reduce macrophage infiltration and fibrosis, and improve TAC-induced cardiac diastolic and systolic functions (132, 133)."
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"Therefore, pirfenidone inhibits NLRP3 activation partially by suppressing the generation of ROS.Despite remarkable advances in our understanding the pathophysiology of ARDS and clinical management of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Li et al. discovered that pirfenidone could inhibit the activation of NLRP3 inflammasome, which may be promising therapeutic strategy for ARDS."
| PMC