IndraLab

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USP3 binds Histone. 2 / 2

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"USP3 does in fact interact with ubiquitinated H2A-type histones, and mouse embryonic fibroblasts isolated from USP3-null mice express increased levels of ubiquitinated H2A [ xref ]."

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"Experiments confirmed that mutation of UBP ZnF significantly reduced the interaction of USP3 with ubiquitinated histone uH2A both in vivo and in vitro, suggesting that this is the major domain mediating the interaction between USP3 and ubiquitin [ xref ]."

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IndraLab

Statements

USP3 binds Histone. 2 / 2

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