IndraLab

Statements

USP19 activates cell migration. 5 / 5
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"In the same study, knockdown of total USP19 inhibited MDA-MB-231 cell migration [51]; this is consistent with the finding that the depletion of USP19-CY, which is the major isoform in MDA-MB-231 cells, also inhibited cell migration."
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"In contrast, USP19-CY promotes TGF-β/SMAD-induced breast and lung cancer cell EMT, cell migration and extravasation in vitro and in vivo."
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"Our results showed that USP19 positively regulated GC cell migration through the up-regulation of MMP2 and MMP9 expression and the decrease of cleaved caspase-3 activity in cell models (XREF_FIG and XREF_FIG)."
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"USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer."
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"These results suggest that USP19-CY promotes TGF-β-induced EMT, as well as basal and TGF-β-mediated cell migration and invasion."
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