IndraLab

Statements

Alpha,alpha-trehalose inhibits mutated ATXN3. 2 / 2
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"However, we observed that trehalose significantly decreased the diameter of mutant ataxin-3 aggregates in a representative lobule (lobule IX) of the cerebellum (Control = 1.91 +/-0.03 microm; 2% trehalose = 1.80 +/-0.03 microm; p = 0.0197; Fig."
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"Trehalose reduces cerebellar atrophy and mutant ataxin-3 aggregate size in Purkinje cells of Machado-Joseph disease transgenic mice."
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