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Tolterodine inhibits KCNH2. 5 / 6
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"The IC50 for hERG block (37 degrees C) by tolterodine was 9.6 nM and by terodiline was 375 nM, values near or below clinical concentrations."
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"Tolterodine block of HERG displayed a positive voltage dependence, suggesting an interaction with an activated state."
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"In vitro studies have shown that tolterodine is a blocker of hERG and that prolongs the APD [63]."
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"However, the molecular mechanism of hERG channel inhibition by tolterodine is largely unclear."
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"For example, tolterodine inhibited hERG currents in Chinese hamster ovary cells ( Kang et al., 2004 ) and human embryonic kidney 293 cells ( Martin et al., 2006 ), with IC 50 values of 17 and 9.6 nM, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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