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VCPIP1 activates viral transcription. 2 / 2
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"In all these models, exogenous overexpression of VCPIP1 resulted in the elevation of viral transcription, increased production of secreted HBsAg and HBeAg, and more importantly, higher levels of intracellular capsids and capsid-associated progeny HBV DNA (Fig. 2A)."
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"In Huh7 cells transfected with p1.3HBV(X ) or pCMV-1.1HBV(X ), knockdown of endogenous VCPIP1 expression reduced viral transcription, production of secreted viral antigens, as well as progeny viral genome replication, whereas exogenous expression of VCPIP1 displayed the opposite effects (Fig. 4)."
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