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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP18 inhibits reactive oxygen species. 2 / 2

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"Interestingly , USP18 inhibition promotes the antibacterial effect of TNFalpha and subsequently induces reactive oxygen species ( ROS ) , thereby controlling primary and secondary bacterial infection , which suggests the therapeutic potential of targeting USP18 in patients to ameliorate disease caused by serious bacterial infections ."

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"Consistent with our finding that Usp18 Ity9 mice have deregulated autophagy marker expression following Salmonella infection in vivo, we also observed that Usp18 Ity9 macrophages have decreased ROS production after exposure to heat killed Salmonella (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...