IndraLab

Statements

USP18 inhibits reactive oxygen species. 2 / 2
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eidos
"Interestingly , USP18 inhibition promotes the antibacterial effect of TNFalpha and subsequently induces reactive oxygen species ( ROS ) , thereby controlling primary and secondary bacterial infection , which suggests the therapeutic potential of targeting USP18 in patients to ameliorate disease caused by serious bacterial infections ."
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reach
"Consistent with our finding that Usp18 Ity9 mice have deregulated autophagy marker expression following Salmonella infection in vivo, we also observed that Usp18 Ity9 macrophages have decreased ROS production after exposure to heat killed Salmonella (XREF_FIG)."
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