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LY294002 inhibits RELA. 11 / 16
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"Of note, Gas6 dependent AKT activation was responsible for the nuclear translocation of the anti-apoptotic NF-kappaB subunit p65, since it was detected in nuclear extracts of LX2 cells immediately after rGas6 administration, while PI3K inhibitor LY294002 blocked p65 nuclear upregulation."
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"The presumption that the PI3-kinase/Akt cascade represents the postulated statin-sensitive NF-κB inducing pathway in endothelial cells was supported by the finding that Ly294002, a specific inhibitor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To verify the molecular mechanism of cornuside in regulating the transformation of reactive astrocytes, LY294002 and Nrf2 silencing were demonstrated to abolish the induction of AKT activation, localization of nuclear Nrf2, and activation of IκB-α, as well as the reduction in p-NF-κB p65 mediated by cornuside."
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"Furthermore, GMPH inhibited nuclear transcription factor kappa-B (NF-kappaB) activation by suppressing the nuclear translocation of NF-kappaB p65, which was markedly reversed by LY294002, an Akt inhibitor."
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"The nucleation of p65 was detected by immunofluorescence analysis ( Fig. 6 E and F), demonstrating that LY294002 pretreatment significantly inhibited the nucleation of p65."
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"Inhibition of PI3K and Akt signaling with LY294002 increased p65 in the nucleus in IL-lbeta+ IFNgamma -stimulated hepatocytes and reversed the dbcAMP induced suppression of nuclear p65 (XREF_FIG)."
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"In the present study, NF-kappaB (p65) expression was decreased in the EC109 cells treated with metformin or LY294002, but increased in insulin treated EC109 cells pretreated with or without metformin."
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"Knockdown of TIPE2 did not affect AKT, p65 or IκBα, but significantly improved the phosphorylation of these factors after LPS stimulation, which was inhibited by pretreatment with LY294002, thereby in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, LY294002 abolished the HCH-induced reduction in NF-κB p65 positive cells (10.5%)."
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"However, treatment of CZC24832 but not LY294002 significantly attenuated CLP-induced NF-κB p65 activation in the heart (Figure 7E)."
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"Both LY294002 and parthenolide inhibited EGF induced nuclear accumulation of NF-kappaB p65."
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