IndraLab

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USP28 activates CDKN1A. 3 / 3
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"Consistent with the notion that deubiquitination of ub-K119-H2A leads to transcriptional activation, we showed that depletion of USP28 inhibits the transcriptional activity of p53, p21 and p16 INK4a ."
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"We showed that 53BP1 and USP28 are required to trigger p53 and p21- dependent cell cycle arrest, evoking an irreversible stress response that selects against unfit cells with disturbed mitosis (XREF_FIG)."
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"USP28 overexpression increased the levels of multiple senescence markers, including p53, p21 , and GATA4 proteins but not p16, again suggesting that USP28 may be inducing senescence in part through the p53 and GATA4 branches (Fig. 3C–E; Supplemental Fig. S3K,L)."
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