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Viral process activates USP18. 3 / 3

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"USP18 , a protein of 368 aa in length and an ISG15 isopeptidase , is a negative regulator of type I and III IFN-activated JAK / STAT signaling [ 142 ] , and is rapidly upregulated by viral infection and IFNs ."

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"USP18 has been known to be induced by viral infection , genotoxic stress or interferon [ 97 ] ."

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"USP18 is promptly induced by viral infection and IFN signaling [ 46 ] ."

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Viral process activates USP18. 3 / 3

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