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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Viral process activates USP18. 3 / 3

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"USP18 , a protein of 368 aa in length and an ISG15 isopeptidase , is a negative regulator of type I and III IFN-activated JAK / STAT signaling [ 142 ] , and is rapidly upregulated by viral infection and IFNs ."

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"USP18 has been known to be induced by viral infection , genotoxic stress or interferon [ 97 ] ."

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"USP18 is promptly induced by viral infection and IFN signaling [ 46 ] ."

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Viral process activates USP18. 3 / 3

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