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Melatonin inhibits CASP1. 20 / 24
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"An additional new finding is the demonstration that melatonin inhibits hypoxia induced caspase-1 activation."
19299628
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"Methazolamide and melatonin inhibit oxygen and glucose deprivation -- induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors, pro--IL-1beta processing, and activation of caspase-1 and -3 in primary cerebrocortical neurons."
19299628
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"Regarding the inhibition of caspases, research has found that melatonin can reduce pyroptosis and autophagy in brain neurons of STZ-induced diabetic mice by targeting caspase-1 through miR-214-3p [101]."
39125694
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"We determined whether melatonin inhibits Rip2 accumulation and counters caspase-1 activation."
21994366
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"Thus, melatonin prevents the activation of the NLRP3 inflammasome and the formation of caspase 1 as well as IL-1β (Figure 3) [93]."
35806441
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"Morphine treatment caused a dramatic morphological change of the cells and a perinuclear aggregation of Caspase-1, which could be abolished by a pretreatment with melatonin (Fig. S4A)."
32413745
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"Moreover, MT inhibited the activation of the NF-kappaB pathway, and reduced the expression of inflammation related proteins (iNOS and COX-2), and pyroptosis related proteins (NLRP3, caspase-1, and GSDMD)."
33842634
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"Likewise, as shown in Figures XREF_FIG and XREF_FIG, the proportion of double positive cells (activated caspase-1 and PI) analyzed with flow cytometry was obviously increased after radiation (7.39 +/-2.27%), while the caspase-1 + PI + cells were significantly attenuated by melatonin (4.65 +/-1.54%, p < 0.05)."
30755784
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"As demonstrated by immunoblotting and complementary fluorogenic assay, melatonin inhibits mutant htt induced caspase-1 activation (XREF_FIG)."
21994366
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"Given that melatonin inhibits caspase-1 activation, we determined if this effect involves blocking Rip2 upregulation."
21994366
eidos
"Melatonin reduced NLRP3 , caspase-1 and ASC speck formation ."
31327964
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"Thus, melatonin prevents the activation of the NLRP3 inflammasome and caspase-1, as well as IL-1β [35,38]."
38136651
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"Consistent with our observations in cellular models for HD (XREF_FIG), we found that melatonin inhibits Rip2 upregulation and caspase-1 activation in R6/2 mice (XREF_FIG)."
21994366
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"The key roles of active caspase 1 involve the cleavage of IL-1β, IL-18 and N-GSDMD to induce pyroptotic cell death and excessive levels of cytokines.In conclusion, our research revealed that melatonin could prevent Aβ-induced inflammasome signaling by inhibiting NLRP3, ASC and caspase 1 to induce excessive cytokine release and pyroptosis by decreasing N-GSDMD levels (Fig. 8)."
37857668
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"Addition of melatonin was able to prevent caspase-1 induction only in co-treatment and not in post-treatment on M1-like microglia."
35750198
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"Melatonin inhibits the caspase-1 and cytochrome c/caspase -3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis."
29902071
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"This indicates that melatonin treatment can reduce the synthesis and release of inflammatory cytokines by inhibiting the activity of caspase-1 (Fig. 3D)."
38665558
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"Melatonin was demonstrated to reduce lipopolysaccharide (LPS)-induced inflammation and the formation of the NLRP3 inflammasome in mouse adipocytes, thus inhibiting caspase-1 and IL-1 activation and the NLRP3 inflammasome-mediated pyroptosis [31,32]."
36902233
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"We recently reported that melatonin inhibits caspase-1 activation in an experimental model of cerebral ischemia."
21994366
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"Melatonin inhibits the caspase-1 and cytochrome c/caspase -3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis."
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