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Melatonin inhibits CASP1. 12 / 15
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"Likewise, as shown in Figures XREF_FIG and XREF_FIG, the proportion of double positive cells (activated caspase-1 and PI) analyzed with flow cytometry was obviously increased after radiation (7.39 +/-2.27%), while the caspase-1 + PI + cells were significantly attenuated by melatonin (4.65 +/-1.54%, p < 0.05)."
30755784
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"Consistent with our observations in cellular models for HD (XREF_FIG), we found that melatonin inhibits Rip2 upregulation and caspase-1 activation in R6/2 mice (XREF_FIG)."
21994366
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"Melatonin inhibits the caspase-1 and cytochrome c/caspase -3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis."
23537713
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"We determined whether melatonin inhibits Rip2 accumulation and counters caspase-1 activation."
21994366
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"Morphine treatment caused a dramatic morphological change of the cells and a perinuclear aggregation of Caspase-1, which could be abolished by a pretreatment with melatonin (Fig. S4A)."
32413745
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"Given that melatonin inhibits caspase-1 activation, we determined if this effect involves blocking Rip2 upregulation."
21994366
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"Moreover, MT inhibited the activation of the NF-kappaB pathway, and reduced the expression of inflammation related proteins (iNOS and COX-2), and pyroptosis related proteins (NLRP3, caspase-1, and GSDMD)."
33842634
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"As demonstrated by immunoblotting and complementary fluorogenic assay, melatonin inhibits mutant htt induced caspase-1 activation (XREF_FIG)."
21994366
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"Methazolamide and melatonin inhibit oxygen and glucose deprivation -- induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors, pro--IL-1beta processing, and activation of caspase-1 and -3 in primary cerebrocortical neurons."
19299628
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"We recently reported that melatonin inhibits caspase-1 activation in an experimental model of cerebral ischemia."
21994366
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"An additional new finding is the demonstration that melatonin inhibits hypoxia induced caspase-1 activation."
19299628
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"Melatonin reduced NLRP3 , caspase-1 and ASC speck formation ."
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