IndraLab

Statements

PKA binds PPP1, AKAP9, KCNQ1, and sch1. 1 / 1

| 1

sparser

"Notably, I KS activity is tightly regulated by PKA-dependent phosphorylation, and this phosphorylation is tuned by both local PKA and PP1 signaling cascades. xref In heart, yotiao directly associates with Kv7.1 to recruit both PKA and PP1 to regulate I KS phosphorylation and gating ( xref ). xref Moreover, the LQT1-causative mutation, G589D abolishes Kv7.1’s association with yotiao thereby disrupting the channel’s sensitivity to beta-adrenergic regulation. xref "

20724725

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

PKA binds PPP1, AKAP9, KCNQ1, and sch1. 1 / 1

INDRA sources:

Databases

Reading