IndraLab

Statements

USP7 inhibits proteolysis. 5 / 5
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"Specifically, HAUSP inhibition drives the proteolysis of both negative regulators of p53, Mdm2 and Mdmx, which subsequently decreases the ubiquitinated-p53forms leading to a total increase in p53 protein levels."
29616860
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"This finding led us to believe that the inhibition of ETS2’s transcriptional activity by USP39 is at least partly due to its effect on the nuclear localization of ETS2.In a recent study, Park et al. demonstrated that the suppression of USP7 led to the inhibition of ETS2 deubiquitination and promoted its protein degradation [18]."
37892157
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"USP7 broadly rescues protein degradation in UbVS and ubiquitin treated extract."
33417828
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"As USP7 was the most efficient DUB in rescuing degradation, we next investigated how broadly USP7 could rescue protein degradation in UbVS and ubiquitin treated extract."
33417828
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"Altogether, our data reveal the dual effect of USP7-mediated TRAF6 signal transduction and USP7-mediated protein degradation of STING in osteoclast formation."
37199589