IndraLab

Statements


USP14 inhibits AR. 4 / 5
| 4

reach
"Hence, we proposed that inhibition or silence of USP14 induced AR downregulation is through enhancing the degradation of AR."

reach
"We found that both IU1 and USP14 siRNA dramatically decreased the PSA mRNA but not the AR mRNA, indicating that USP14 inhibition or gene silence does not affect the transcription of AR (XREF_FIG)."

reach
"Both genetic knockdown and pharmacological inhibition of USP14 inhibits the proliferation and induces the apoptosis of AR-positive breast cancer cells (Table 2)."

reach
"We therefore hypothesized that inhibition or silencing of USP14 could induce AR downregulation through enhancing AR degradation."