IndraLab

Statements

TP53 binds CDKN1A and MDM2. 16 / 16
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"The treatment of NIH3T3 cells with CoCl 2 was associated with the induction of p53-target genes p21 and Mdm2 ( Fig. S3 )."
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"YY1 negatively regulates CDKN3 expression by directly binding to the promoter region of CDKN3, and the decrease in CDKN3 expression inhibits the formation of the MDM2-P53 complex, which in turn upregulates P21 expression."
33985581
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"We showed that the extent of p53 binding to the p21 and MDM2 promoters was increased in MCF7 cells upon treatment with doxorubicin or camptothecin ( xref , bottom panels, compare lanes 1 and 7 with lanes 3, 5, 10, and 12, respectively)."
20473326
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"High p53 expression levels are associated with elevated Mdm2 levels and a loss of p21(Waf1/Cip1) expression suggesting a changed functionality of p53."
16099193
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"For example, p53 β bound preferentially to BAX andp21 WAF1 promoters rather than MDM2 promoter, whereas p53 bound preferentially top21 WAF1 and MDM2 promoters than to BAX promoter [ xref ]."
21188172
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"In HMECs infected with HCMV-DB, we observed decreased binding of p53 to endogenous p53-responsive promoters of p21 and MDM2 genes as shown by chromatin immunoprecipitation ( Fig. 3 c)."
29628341
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"Furthermore, overexpression of mdm2, which directly interacts with the p53 and p21 promoters, results in uncontrolled cell transition to the S phase and their transformation [24, 29– xref , xref , xref , xref ]."
23150808
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"P53 β binds preferentially the p53-responsive promoters p21 and Bax rather than Mdm2, whereas p53 binds preferentially to Mdm2 and p21 rather than Bax promoters."
17637683
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"P53β binds preferentially the p53-responsive promoters p21 and Bax rather than Mdm2, while p53 binds preferentially to Mdm2 and p21 rather than Bax promoters."
18289041
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"In p53 wild type cells, BCCIP knock down by RNA interference diminishes the transactivation activity of p53 without reducing the p53 protein level, inhibits the binding of p53 to the promoters of p53 target genes p21 and HDM2, and reduces the tetrameric formation of p53."
17135243
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"MDM2 can also directly interact with p21 in a p53-independent manner and enhance its degradation [ xref ], MDM2 also mediates the ubiquitin-independent proteasomal degradation of p21 [ xref ]."
22830335
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"ChIP assay showed that p53 protein could bind to the promoter regions of the positive control genes MDM2 and p21 (p < 0.05) in NPCs to significantly regulate their transcriptional expression."
32071547
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"Mutation of TP53 gene was associated with abolished induction of p21(Waf1/Cip1) and MDM-2 proteins and resistance to apoptosis after genotoxic treatment."
20193843
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"The level of p53 binding to the CDKN1A (p21) or MDM2 promoter with higher affinity is increased significantly; however, the level of p53 binding to the PIG3 promoter with lower affinity is minor, which results in a lower PIG3 mRNA level [ xref ]."
33955710
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"Consistently, ChIP-PCR showed significantly reduced p53 binding to the p21 and MDM2 promoters in LFS OBs ( xref )."
25860607
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"In p53 wild type cells, BCCIP knockdown by RNAi diminished the transactivation activity of p53, inhibited the binding of p53 to promoters of p53 target genes p21 and HDM2, and reduced the tetrameric formation of p53 [ xref ]."
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