IndraLab

Statements

MDM2 binds TP53 and CDKN1A. 13 / 13
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"In p53 wild type cells, BCCIP knockdown by RNAi diminished the transactivation activity of p53, inhibited the binding of p53 to promoters of p53 target genes p21 and HDM2, and reduced the tetrameric formation of p53 [ xref ]."
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"ChIP assay showed that p53 protein could bind to the promoter regions of the positive control genes MDM2 and p21 (p < 0.05) in NPCs to significantly regulate their transcriptional expression."
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"For example, p53 β bound preferentially to BAX andp21 WAF1 promoters rather than MDM2 promoter, whereas p53 bound preferentially top21 WAF1 and MDM2 promoters than to BAX promoter [ xref ]."
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"P53β binds preferentially the p53-responsive promoters p21 and Bax rather than Mdm2, while p53 binds preferentially to Mdm2 and p21 rather than Bax promoters."
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"YY1 negatively regulates CDKN3 expression by directly binding to the promoter region of CDKN3, and the decrease in CDKN3 expression inhibits the formation of the MDM2-P53 complex, which in turn upregulates P21 expression."
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"P53 β binds preferentially the p53-responsive promoters p21 and Bax rather than Mdm2, whereas p53 binds preferentially to Mdm2 and p21 rather than Bax promoters."
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"The treatment of NIH3T3 cells with CoCl 2 was associated with the induction of p53-target genes p21 and Mdm2 ( Fig. S3 )."
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"The level of p53 binding to the CDKN1A (p21) or MDM2 promoter with higher affinity is increased significantly; however, the level of p53 binding to the PIG3 promoter with lower affinity is minor, which results in a lower PIG3 mRNA level [ xref ]."
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"In p53 wild type cells, BCCIP knock down by RNA interference diminishes the transactivation activity of p53 without reducing the p53 protein level, inhibits the binding of p53 to the promoters of p53 target genes p21 and HDM2, and reduces the tetrameric formation of p53."
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"MDM2 can also directly interact with p21 in a p53-independent manner and enhance its degradation [ xref ], MDM2 also mediates the ubiquitin-independent proteasomal degradation of p21 [ xref ]."
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"Furthermore, overexpression of mdm2, which directly interacts with the p53 and p21 promoters, results in uncontrolled cell transition to the S phase and their transformation [24, 29– xref , xref , xref , xref ]."
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"Consistently, ChIP-PCR showed significantly reduced p53 binding to the p21 and MDM2 promoters in LFS OBs ( xref )."
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"We showed that the extent of p53 binding to the p21 and MDM2 promoters was increased in MCF7 cells upon treatment with doxorubicin or camptothecin ( xref , bottom panels, compare lanes 1 and 7 with lanes 3, 5, 10, and 12, respectively)."
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