IndraLab

Statements

Simvastatin inhibits STAT1. 7 / 7
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"STAT1 is also phosphorylated by IL-12, a cytokine that induces IFN-gamma production, and certain STAT1 mutations in humans result in decreased IFN-gamma production after IL-12 stimulation, suggesting that STAT1 inhibition by simvastatin may have effects upstream of IFN-gamma production as well."
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"Interestingly, simvastatin modulates the detrimental effects of high glucose and ANG II in diabetic kidney glomeruli both in vitro and in vivo by preventing the high glucose and ANG II induced geranylgeranyl dependent activation of Rac or/and Rho and thereby blocking the activation of JAK2 and both STAT1 and STAT3 [XREF_BIBR]."
32375786
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"Activation of signal transducer and activator of transcription 1 (STAT1) is required for IFN-gamma signaling and recent studies revealed that simvastatin, an FDA approved cholesterol lowering medication, inhibited STAT1 activation in vitro."
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"A recent study reported that simvastatin, an HMG-CoA reductase inhibitor approved by the FDA for the treatment of hypercholesterolemia, inhibited IFN-gamma-induced STAT1 activation in vitro."
25521459
ctd
No evidence text available
19886038
reach
"This is consistent with previous observations that the IFN-gamma-signaling pathway is critical for both the progression and maintenance of depigmentation in our mouse model), that STAT1 activation is required for IFN-gamma signaling, that simvastatin inhibits IFN-gamma-induced STAT1 activation in vitro, and that simvastatin reversed depigmentation in a patient with vitiligo."
25521459
reach
"STAT1 activation is required for IFN-gamma signaling and recent studies revealed that simvastatin, an FDA approved cholesterol lowering medication, inhibited STAT1 activation in vitro."
25521459