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Modified AGAP3 activates mutated ATXN3. 1 / 1

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"Overexpression of the CRAG protein, which is an activator of promyelocytic leukemia protein associated ubiquitin ligase, enhances the ubiquitination and proteasome clearance of mutant ataxin-3 and ultimately leads to improvements in both motor and neurological phenotypes in polyQ69 mice [XREF_BIBR]."

22944909

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IndraLab

Statements

Modified AGAP3 activates mutated ATXN3. 1 / 1

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