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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified AGAP3 activates mutated ATXN3. 1 / 1

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"Overexpression of the CRAG protein, which is an activator of promyelocytic leukemia protein associated ubiquitin ligase, enhances the ubiquitination and proteasome clearance of mutant ataxin-3 and ultimately leads to improvements in both motor and neurological phenotypes in polyQ69 mice [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...