IndraLab

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USP18 activates ferroptosis. 3 / 3
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"Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis."
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"In summary, USP18 knockdown inhibited proliferation, migration but enhanced apoptosis and ferroptosis in LUAD cells."
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"We further confirmed that USP18 modulation of ferroptosis was through SLC7A11, since ectopic SLC7A11 expression largely rescued ferroptotic cell death induced by Erastin and enhanced by USP18 knockdown (Fig. 6H and SI Appendix, Fig. S7M)."
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