IndraLab

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USP20 activates HYCC1. 6 / 6
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"Targeting USP20 may mitigate the development of drug resistance and promote ferroptosis of HCC in patients receiving chemotherapy.2 RESULTS."
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"Huh‐7, Hep3B, and HCC primary cell line were treated with increasing concentration of a glutamate–cystine antiporter system Xc− inhibitor (erastin), and found that USP20 depletion inhibited the viability of HCC cells, and cells depleted with USP20 were more sensitive to ferroptosis induced by erastin treatment (Figures 2A–C and S2E)."
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"Therefore, targeting USP20 may mitigate the development of drug resistance and promote ferroptosis of HCC in patients receiving chemotherapy.4 METHODS."
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"We observed that USP20 depletion remarkably inhibited the oncosphere formation of Huh‐7, Hep3B and HCC primary cells (Figures S2K, S5A, andB)."
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"We also observed that knockdown or pharmacologically inhibition of USP20 could significantly reduce the proliferation and viability of HCC cells, which was consistent with previous studies."
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"Therefore, targeting USP20 may mitigate the development of drug resistance and promote ferroptosis of HCC in patients receiving chemotherapy."
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