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BRCC3 activates K63Ub deubiquitinase. 1 / 1

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"In this way, BRCA1-A (i) accumulates BRCA1 at DSBs via RAP80-mediated recognition of Lys63-linked ubiquitin (K63Ub) adducts in the damaged chromatin [9, 15, 18], (ii) terminates the DDR via BRCC36-mediated K63Ub deubiquitinase (DUB)-activity [19] and (iii) prevents over-resection through sequestration of BRCA1 to the flanks of the DSBs, thereby depleting the local pool of BRCA1 available to enhance DNA end-resection by BRCA1-C [20]."

37198153

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BRCC3 activates K63Ub deubiquitinase. 1 / 1

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