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EIF3F deubiquitinates PHGDH. 5 / 5
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"Furthermore, eIF3f exerts its oncogenic function by deubiquitinating PHGDH and MYC, which subsequently enhances SGOC pathway to promote CRC progression."
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"22 Based on the findings, it is possible that eIF3f may deubiquitinate PHGDH."
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"Taken together, eIF3f deubiquitinates PHGDH independent of translation regulation.2.3 FBXW7beta-Mediated PHGDH Ubiquitination through Binding the Phosphodegron of PHGDH in a GSK3beta-Dependent Manner."
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"To further understand the mechanism of eIF3f‐mediated PHGDH deubiquitylation, we investigate the ubiquitin E3 ligase for PHGDH in CRC."
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"Likewise, Pan et al[33] recently revealed that PHGDH can serve as a novel substrate for GSK3β/FBXW7β, and that eIF3f can enhance the serine one-carbon metabolic pathway to promote CRC progression by deubiquitinating PHGDH."
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