IndraLab

Statements

CYLD activates LCK. 4 / 4
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"In regulating T-cell receptor (TCR) signaling during the transition from DP thymocytes to mature SP thymocytes, CYLD targets the tyrosine kinase LCK, playing a critical role in this transition."
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"Specifically, CYLD positively regulates LCK in thymocytes and negatively regulates TAK1 in peripheral T cells XREF_BIBR, XREF_BIBR."
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"We have previously shown that CYLD positively regulates LCK function and TCR proximal signaling in thymocytes."
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"In contrast to its negative role in the regulation of NF-kappaB, CYLD positively regulates LCK 18, a SRC family protein tyrosine kinase that is required for TCR proximal signalling and thymocyte development 77."
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