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USP46 decreases the amount of STK4. 3 / 3
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"Third, USP46 silencing increased ubiquitination levels of MST1, whereas overexpression of USP46 decreased levels of MST1 ubiquitination.In conclusion, we found that USP46 interacts with MST1 and decre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Finally, ectopic expression of USP46 inhibited the ubiquitination level of MST1, whereas knockdown of USP46 increased the polyubiquitination of MST1 ( Fig. 6 G and H)."

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"Therefore, we speculated that USP46 suppressed YAP1 by regulating MST1 protein expression in HCC."